As always, it didn't disappoint!
The first celeb on the chopping block? George Clooney!
"i'm very much looking forward to the day when the world stops sucking george clooney's t--t," the actor read. "Lumpy faced basterd." Clooney's reply? "F--ck you @seauxphie."
We love the actor's response!
Check out the video above to see the hilariously awful things people have tweeted Tom Hanks, Jennifer Garner, Jon Hamm, Rob Lowe, Matt Damon, Cate Blanchett and more!
Which "Mean Tweet" was your favorite? Sound off below!